Spider-Manhas arguably the most recognizable villains' rogues gallery in Marvel Comics.

The Chameleon

Spider-Man’s first appearance was in Amazing Fantasy #15.

However, the villain in that comic was a thief and killer and not a true supervillain.

Characters from Hospital Playlist and Business Proposal are edited in a collage.

This was hugely important as Chameleon was part of why no one trusted Spider-Man for years into his career.

This wasAdrian Toomes, who had wings he created as a brilliant scientist.

This didn’t show his origin story and what caused him to become a villain.

Imagery from The Substance and Companion

Spider-Man also battled a secondary villain in this issue known as The Tinkerer.

This put the very smart teenage Peter Parker up against the brilliant Otto Octavius for the first time.

He eventually tries to take over a nuclear power plant before Spider-Man stops him.

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Sandman

Sandman shows up for the first time inAmazing Spider-Man#4.

Spider-Man then has to use his brains to figure out how to stop the slippery villain.

This battle put Spider-Man up against the Fantastic Four’s arch-nemesis, Doctor Doom.

Mysterio and Doctor Octopus as two of Spider-Man’s enemies.

However, they ended up battling instead.

This was the first time Spider-Man didn’t capture the villain, as Doctor Doom escaped.

Lizard

InAmazing Spider-Man#6, Spider-Man battled his first sympathetic villain.

Chameleon sitting in front of his masks.

Spider-Man goes to Florida to stop The Lizard.

Instead, Spider-Man decides to save Curt Connors rather than send him to prison.

Connors eventually became a quasi-ally for Spider-Man.

Vulture flying as he prepares to fight Spider-Man.

The Living Brain was a computer that could answer any question if given the correct input.

The scientist who created it would bring it back years later.

Electro

InAmazing Spider-Man#9, the Wall-Crawler battled Electro for the first time.

Doctor Octopus watching over Spider-Man from Marvel Comics

Mysterio

The 10th supervillain that Spider-Man ever fought came inAmazing Spider-Man#13.

This was Mysterio, who actually made his first appearance behind the scenes inAmazing Spider-Man#2.

Here, Mysterio pulled the same stunt that Chameleon did, pretending to be Spider-Man and robbing several businesses.

Sandman splits himself up to battle Spider-Man.

Spider-Man had to prove his innocence by beating the new villain.

TheKraven’s Last Huntstoryline remains one of the best in Spider-Man history.

However, their appearance in Spider-Man’s early comics came with an even bigger debut.

Doctor Doom ruling over his country of Latveria.

This was Mac Gargan, the Scorpion.

The villain appeared here afterJ.

Jonah Jameson paid to have Mac given superhuman powersto take a stab at bring down Spidey.

The Lizard roams the sewers.

The Beetle

In Amazing Spider-Man #21, it was time for another team-up.

The villain debuted inFantastic Fourcomics, so it was no surprise that the Torch would show up here.

After this, Beetle became more of a Spider-Man villain than one for the Human Torch.

The Living Brain preparing to attack.

The Spider-Slayer

J. Jonah Jameson became one of Spider-Man’s most persistent antagonists for many years.

This included the introduction of the Spider-Slayer inAmazing Spider-Man#25.

In this book, Jameson helped finance the creation of the Spider-Slayer by Spencer Smythe.

Electro and Spider-Man locked in battle from Marvel Comics

Jameson actually controls the Spider-Slayer here, but Spider-Man beats it pretty easily.

NEXT:10 Biggest Differences Between Spider-Man In The Movies And Comics

Spider-Man prepares to fight The Enforcers.

Mysterio preparing to cast an illusion.

Kraven the Hunter’s first appearance in Spider-Man.

Ringmaster leading his Circus of Crime.

Scorpion lifting Spider-Man.

Human Torch and Spider-Man fighting The Beetle.

J Jonah Jameson using a Spider-Slayer to attack Spider-Man.